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dc.contributor.authorBriley, Paul M
dc.contributor.otherWebster, Lucy
dc.contributor.otherOh, Hyerin
dc.contributor.otherPszczolkowski, Stefan
dc.contributor.otherCottam, William J
dc.contributor.otherKaylor-Hughes, Catherine
dc.contributor.otherIwabuchi, Sarina
dc.contributor.otherLankappa, Sudheer
dc.contributor.otherAuer, Dorothee P
dc.contributor.otherLiddle, Peter F
dc.contributor.otherMorriss, Richard
dc.description.abstractThis is the statistical analysis plan for a set of mechanism of action studies for the BRIGhTMIND clinical trial of transcranial magnetic stimulation for major depressive disorder. This statistical analysis plan concerns testing of hypotheses that motivated the trial itself and thus were specified in the NIHR Efficacy and Mechanism Evaluation (EME) funding application. There will be two such analysis plans - the present one concerns analyses of resting-state functional magnetic resonance imaging (fMRI) data. The second, to be published separately, concerns analyses of magnetic resonance spectroscopy (MRS) data. Details about the trial itself can be found in the main trial protocol paper (Morriss et al., 2020, doi: 10.1136/bmjopen-2020-038430). Further details on the imaging analysis steps conducted as part of trial delivery can be found in the published magnetic resonance imaging protocol paper (Pszczolkowski et al., 2022, doi: 10.2196/31925).en_UK
dc.publisherThe University of Nottinghamen_UK
dc.subject.lcshMagnetic resonance imagingen_UK
dc.subject.lcshMagnetic brain stimulationen_UK
dc.subject.lcshDepression, Mentalen_UK
dc.titleBRIGhTMIND trial-motivating mechanism of action analysis plan: resting-state fMRIen_UK
dc.subject.freeBRIGhTMIND, transcranial magnetic stimulation, TMS, functional magnetic resonance imaging, fMRIen_UK
dc.subject.jacsSubjects Allied to Medicine::Anatomy, physiology & pathology::Neuroscienceen_UK
dc.subject.lcR Medicine::RC Internal medicine::RC 321 Neuroscience. Biological psychiatry. Neuropsychiatryen_UK
uon.divisionUniversity of Nottingham, UK Campus::Faculty of Medicine and Health Sciences::School of Medicineen_UK
uon.funder.controlledNational Institute for Health Researchen_UK
uon.datatypePDF documenten_UK
uon.grantEME Project:16/44/22en_UK
uon.collectionmethodStatistical Analysis Planen_UK
uon.institutes-centresUniversity of Nottingham, UK Campus::Mental Health, Institute ofen_UK

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