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Design and evaluation of new quinazolin-4(3H)-one derived PqsR antagonists as quorum sensing quenchers in Pseudomonas aeruginosa

dc.contributor.authorSoukarieh, Fadi
dc.contributor.otherMashabi, Alaa
dc.contributor.otherRichardson, William
dc.contributor.otherVico Oton, Eduard
dc.contributor.otherRomero, Manuel
dc.contributor.otherRobertson, Shaun
dc.contributor.otherGrossman, Scott
dc.contributor.otherSou, Tomas
dc.contributor.otherLiu, Ruiling
dc.contributor.otherHalliday, Nigel
dc.contributor.otherKukavica-Ibrulj, Irena
dc.contributor.otherLevesque, Roger
dc.contributor.otherBergstrom, Christel
dc.contributor.otherKellam, Barrie
dc.contributor.otherEmsley, Jonas
dc.contributor.otherHeeb, Stephan
dc.contributor.otherWilliams, Paul
dc.contributor.otherStocks, Michael
dc.contributor.otherCámara, Miguel
dc.date.accessioned2022-04-22T07:54:20Z
dc.date.available2022-04-22T07:54:20Z
dc.date.issued2022-04-22
dc.identifier.urihttps://rdmc.nottingham.ac.uk/handle/internal/9508
dc.description.abstractA study focused on the design, synthesis and evaluation of pqs quorum sensing inhibitorsen_UK
dc.language.isoenen_UK
dc.publisherThe University of Nottinghamen_UK
dc.rightsCC-BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.lcshPseudomonas aeruginosaen_UK
dc.subject.lcshBiofilmsen_UK
dc.subject.lcshQuorum sensing (Microbiology)en_UK
dc.titleDesign and evaluation of new quinazolin-4(3H)-one derived PqsR antagonists as quorum sensing quenchers in Pseudomonas aeruginosaen_UK
dc.identifier.doihttp://doi.org/10.17639/nott.7190
dc.subject.freePseudomonas aeruginosa, PqsR, Pseudomonas quinolone signal, PQS, biofilms, quorum sensing inhibitionen_UK
dc.subject.jacsBiological Sciences::Microbiology::Bacteriologyen_UK
dc.subject.lcQ Science::QR Microbiologyen_UK
dc.date.collection2015/05 - 2020/12en_UK
uon.divisionUniversity of Nottingham, UK Campus::Faculty of Medicine and Health Sciences::School of Life Sciencesen_UK
uon.funder.controlledBiotechnology & biological Sciences Research Councilen_UK
uon.funder.controlledOtheren_UK
uon.datatypeCrystallography files, Data analysis from reporter strain, imaging, and pyocyanin and LCMSMS analysisen_UK
uon.funder.freeJPIAMRen_UK
uon.grantEP/N006615/1en_UK
uon.grantEP/K005138/1en_UK
uon.grantEP/N03371X/1en_UK
uon.grantN501852/1en_UK
uon.collectionmethodMolecular Docking, Mass spectrometry, NMR, Isothermal Calorimetry, Bioreporter assay, Alkyl quinolone quantification, pyocyanin quantification, PqsR protein expression, Galleria Mellonella survival assay, Microscopy and biofilm formation assayen_UK
uon.institutes-centresUniversity of Nottingham, UK Campusen_UK
uon.preservation.rarelyaccessedtrue
dc.relation.doihttps://doi.org/10.1021/acsinfecdis.1c00175en_UK


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