Elucidating the molecular landscape of the stratum corneum

Abstract

• Characterization of the molecular structure of skin, especially the barrier layer, the stratum corneum using 3D OrbiSIMS. • Understand the chemical variations relating to fundamental biological processes, such as the epidermal cholesterol sulfate. • Investigate the non-homogeneity of the stratum corneum, both laterally and as a function of depth. Including the distribution and localisation of key components in the skin e.g. fatty acids, ceramides and natural moisturising factors. • Demonstrate the permeation of a commercially important anti-aging peptide into human stratum corneum.