Vitiligo Noticeability Scale-validation studies

Abstract

Aim To fill validation gaps for the Vitiligo Noticeability Scale (VNS) so it can be considered for adoption into the vitiligo Core Outcome Set.

Objectives: 1) Test the reliability and interpretability of the VNS using digital images collected in the HI-Light Vitiligo trial 2) Explore how post-treatment hyperpigmentation around vitiligo patches influences the assessment of treatment success, and the value of delaying assessment of the VNS until hyperpigmentation has resolved. 3) Develop a ‘static’ version of the VNS and explore whether ‘static’ or ‘change from baseline’ response options are most meaningful to patients, valid and responsive

Background to data collection We used the VNS as the primary outcome measure in a large NIHR-funded clinical trial (HI-Light). Blinded patient assessors viewed images from the HI-Light trial. Reliability was assessed using test-retest analyses, and interpretability by comparing with global treatment success. The static VNS was developed using focus groups with vitiligo patients, using framework analysis of the data. The new scale was validated using the same methods and analyses as for the original VNS scale.