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Immune-instructive polymers

dc.contributor.authorGhaemmaghami, Amir
dc.contributor.otherRostam, Hassan
dc.contributor.otherFisher, Leanne E
dc.contributor.otherAlexander, Morgan R
dc.contributor.otherHook, Andrew L
dc.contributor.otherBurroughs, Laurence
dc.contributor.otherLuckett, Jeni C
dc.contributor.otherFigueredo, Grazziela P
dc.contributor.otherMbadugha, Chidimma
dc.contributor.otherTeo, Alvin C K
dc.contributor.otherLatif, Arsalan
dc.contributor.otherKammerling, Lisa
dc.contributor.otherDay, Mitchell
dc.contributor.otherLawler, Karen
dc.contributor.otherBarrett, David
dc.contributor.otherElsheikh, Somaia
dc.contributor.otherIlyas, Mohammad
dc.contributor.otherWinkler, David A
dc.date.accessioned2020-05-01T07:02:30Z
dc.date.available2020-05-01T07:02:30Z
dc.date.issued2020-05-01
dc.identifier.urihttps://rdmc.nottingham.ac.uk/handle/internal/8306
dc.description.abstractWe identify polymers which instruct different immunological responses by modulating macrophage attachment and polarisation to pro-inflammatory (M1-like) or anti-inflammatory (M2-like) phenotypes. These immune-instructive polymers were discovered using in-vitro high throughput polymer microarray screening of diverse (meth)acrylate and (meth)acrylamide libraries. The bio-instructive polymer function is validated in-vivo and analysis of the protein layer adsorbed to polymers, cytokine release and phagocytosis explored.en_UK
dc.language.isoenen_UK
dc.publisherThe University of Nottinghamen_UK
dc.rightsCC-BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.lcshPolymersen_UK
dc.subject.lcshRegenerative medicineen_UK
dc.subject.lcshMacrophagesen_UK
dc.subject.lcshImmune responseen_UK
dc.titleImmune-instructive polymersen_UK
dc.typedataset
dc.identifier.doihttp://doi.org/10.17639/nott.7046
dc.subject.freeBio-instructive materials, immune modulation, high throughput polymer screening, machine learning, macrophage, regenerative medicine  en_UK
dc.subject.jacsBiological Sciences::Microbiology::Immunologyen_UK
dc.subject.lcQ Science::QR Microbiology::QR180 Immunologyen_UK
uon.divisionUniversity of Nottingham, UK Campusen_UK
uon.funder.controlledMedical Research Councilen_UK
uon.funder.controlledEngineering & Physical Sciences Research Councilen_UK
uon.datatypeExcell spreadsheets, prism files, jpeg images, bmp image files, powerpoint documenten_UK
uon.funder.freeEPSRC (Next Generation Biomaterials Discovery)en_UK
uon.funder.freeCiC Medical Research Council Granten_UK
uon.grantEP/N006615/1en_UK
uon.collectionmethodMicroscopy, cell profiler, XPS, proteomics gathering, ELISA, immuno stainingen_UK
dc.relation.doihttps://doi.org/10.1016/j.matt.2020.03.018en_UK


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