Immune-instructive polymers

We identify polymers which instruct different immunological responses by modulating macrophage attachment and polarisation to pro-inflammatory (M1-like) or anti-inflammatory (M2-like) phenotypes. These immune-instructive polymers were discovered using in-vitro high throughput polymer microarray screening of diverse (meth)acrylate and (meth)acrylamide libraries. The bio-instructive polymer function is validated in-vivo and analysis of the protein layer adsorbed to polymers, cytokine release and phagocytosis explored.

External URI

https://rdmc.nottingham.ac.uk/handle/internal/8306

DOI

http://doi.org/10.17639/nott.7046

Subjects

Polymers
Regenerative medicine
Macrophages
Immune response
Bio-instructive materials, immune modulation, high throughput polymer screening, machine learning, macrophage, regenerative medicine  
Biological Sciences::Microbiology::Immunology
Q Science::QR Microbiology::QR180 Immunology

Divisions

University of Nottingham, UK Campus

Deposit date

2020-05-01

Data type

Excell spreadsheets, prism files, jpeg images, bmp image files, powerpoint document

Contributors

Rostam, Hassan
Fisher, Leanne E
Alexander, Morgan R
Hook, Andrew L
Burroughs, Laurence
Luckett, Jeni C
Figueredo, Grazziela P
Mbadugha, Chidimma
Teo, Alvin C K
Latif, Arsalan
Kammerling, Lisa
Day, Mitchell
Lawler, Karen
Barrett, David
Elsheikh, Somaia
Ilyas, Mohammad
Winkler, David A

Funders

Medical Research Council
Engineering & Physical Sciences Research Council
EPSRC (Next Generation Biomaterials Discovery)
CiC Medical Research Council Grant

Grant number

EP/N006615/1

Data collection method

Microscopy, cell profiler, XPS, proteomics gathering, ELISA, immuno staining

Resource languages

Publisher

The University of Nottingham

Except where otherwise noted, this item's license is described as Creative Commons by Attribution