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      Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling

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      Figure 1, depth profile data for CN- and PO3- ion (2.593Kb)
      Figure 2, ascorbic acid reference spectrum (13.71Mb)
      Figure 2, ascorbyl glucoside reference spectrum (11.86Mb)
      Supp. Figure 2, gelator reference spectrum (21.09Mb)
      Figure 3/4, Depth profile data, Ascorbic acid/Gel repeat1 (2.005Kb)
      Figure 3/4, Depth profile data, Ascorbic acid/Gel repeat2 (2.001Kb)
      Figure 3/4, Depth profile data, Ascorbic acid/Gel repeat3 (1.990Kb)
      Figure 3/4, Depth profile data, Ascorbic acid/Gel repeat4 (1.986Kb)
      Figure 3/4, Depth profile data, Ascorbic acid/Gel repeat5 (1.991Kb)
      Figure 3/4, Depth profile data, Ascorbic acid/Gel repeat6 (1.983Kb)
      Figure 3/4, Depth profile data, Ascorbic acid/PBS repeat1 (2.014Kb)
      Figure 3/4, Depth profile data, Ascorbic acid/PBS repeat2 (1.985Kb)
      Figure 3/4, Depth profile data, Ascorbic acid/PBS repeat3 (2.009Kb)
      Figure 3/4, Depth profile data, Ascorbic acid/PBS repeat4 (1.992Kb)
      Figure 3/4, Depth profile data, Ascorbic acid/PBS repeat5 (1.993Kb)
      Figure 3/4, Depth profile data, Ascorbic acid/PBS repeat6 (1.989Kb)
      Figure 3/4, Depth profile data, Ascorbyl glucoside/Gel repeat1 (2.799Kb)
      Figure 3/4, Depth profile data, Ascorbyl glucoside/Gel repeat2 (2.771Kb)
      Figure 3/4, Depth profile data, Ascorbyl glucoside/Gel repeat3 (2.770Kb)
      Figure 3/4, Depth profile data, Ascorbyl glucoside/Gel repeat5 (2.777Kb)
      Figure 3/4, Depth profile data, Ascorbyl glucoside/Gel repeat4 (2.776Kb)
      Figure 3/4, Depth profile data, Ascorbyl glucoside/Gel repeat6 (2.766Kb)
      Figure 3/4, Depth profile data, Ascorbyl glucoside/PBS repeat1 (2.790Kb)
      Figure 3/4, Depth profile data, Ascorbyl glucoside/PBS repeat2 (2.764Kb)
      Figure 3/4, Depth profile data, Ascorbyl glucoside/PBS repeat3 (2.770Kb)
      Figure 3/4, Depth profile data, Ascorbyl glucoside/PBS repeat4 (2.775Kb)
      Figure 3/4, Depth profile data, Ascorbyl glucoside/PBS repeat5 (2.768Kb)
      Figure 3/4, Depth profile data, Ascorbyl glucoside/PBS repeat6 (2.768Kb)
      Publication date
      2019-03-15
      Creators
      Starr, Nichola
      Scurr, David
      Metadata
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      Description
      This research explores the use of ToF-SIMS 3D profiling to provide information on the skin permeation of active compounds, specifically vitamin C delivery from different formulation types.
      External URI
      • https://rdmc.nottingham.ac.uk/handle/internal/6178
      DOI
      • http://doi.org/10.17639/nott.6171
      Subjects
      • Colloids
      • Gels (Pharmacy)
      • Vitamin C
      • Skin permeation, supramolecular hydrogel, permeation enhancer, vitamin C, ToF-SIMS, depth profiling.
      • Subjects Allied to Medicine::Anatomy, physiology & pathology
      • Subjects Allied to Medicine::Pharmacology, toxicology & pharmacy
      • Q Science::QD Chemistry::QD 71 Analytical chemistry
      Divisions
      • University of Nottingham, UK Campus::Faculty of Science::School of Pharmacy
      Deposit date
      2019-03-15
      Corporate creators
      • Walgreens Boots Alliance
      Data type
      ToF-SIMS ion intensities presented as text files
      Contributors
      • Khuriah, Abdul Hamid
      • Pérez-García, Luïsa
      Funders
      • Engineering & Physical Sciences Research Council
      • Walgreens Boots Alliance
      • Innovate UK (KTP Partnership)
      • EU ERDF (FEDER) and the Spanish Government
      Grant number
      • EP/I01375X/1
      • KTP grant no. 510929
      • TEC2017-85059-C3-2-R
      Collection dates
      • January 2016-January 2018
      Data collection method
      ToF-SIMS SurfaceLab 6 Software
      Resource languages
      • en
      Publisher
      The University of Nottingham

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