Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling

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Figure 1, depth profile data for CN- and PO3- ion (2.593Kb)

Figure 2, ascorbic acid reference spectrum (13.71Mb)

Figure 2, ascorbyl glucoside reference spectrum (11.86Mb)

Supp. Figure 2, gelator reference spectrum (21.09Mb)

Figure 3/4, Depth profile data, Ascorbic acid/Gel repeat1 (2.005Kb)

Figure 3/4, Depth profile data, Ascorbic acid/Gel repeat2 (2.001Kb)

Figure 3/4, Depth profile data, Ascorbic acid/Gel repeat3 (1.990Kb)

Figure 3/4, Depth profile data, Ascorbic acid/Gel repeat4 (1.986Kb)

Figure 3/4, Depth profile data, Ascorbic acid/Gel repeat5 (1.991Kb)

Figure 3/4, Depth profile data, Ascorbic acid/Gel repeat6 (1.983Kb)

Figure 3/4, Depth profile data, Ascorbic acid/PBS repeat1 (2.014Kb)

Figure 3/4, Depth profile data, Ascorbic acid/PBS repeat2 (1.985Kb)

Figure 3/4, Depth profile data, Ascorbic acid/PBS repeat3 (2.009Kb)

Figure 3/4, Depth profile data, Ascorbic acid/PBS repeat4 (1.992Kb)

Figure 3/4, Depth profile data, Ascorbic acid/PBS repeat5 (1.993Kb)

Figure 3/4, Depth profile data, Ascorbic acid/PBS repeat6 (1.989Kb)

Figure 3/4, Depth profile data, Ascorbyl glucoside/Gel repeat1 (2.799Kb)

Figure 3/4, Depth profile data, Ascorbyl glucoside/Gel repeat2 (2.771Kb)

Figure 3/4, Depth profile data, Ascorbyl glucoside/Gel repeat3 (2.770Kb)

Figure 3/4, Depth profile data, Ascorbyl glucoside/Gel repeat5 (2.777Kb)

Figure 3/4, Depth profile data, Ascorbyl glucoside/Gel repeat4 (2.776Kb)

Figure 3/4, Depth profile data, Ascorbyl glucoside/Gel repeat6 (2.766Kb)

Figure 3/4, Depth profile data, Ascorbyl glucoside/PBS repeat1 (2.790Kb)

Figure 3/4, Depth profile data, Ascorbyl glucoside/PBS repeat2 (2.764Kb)

Figure 3/4, Depth profile data, Ascorbyl glucoside/PBS repeat3 (2.770Kb)

Figure 3/4, Depth profile data, Ascorbyl glucoside/PBS repeat4 (2.775Kb)

Figure 3/4, Depth profile data, Ascorbyl glucoside/PBS repeat5 (2.768Kb)

Figure 3/4, Depth profile data, Ascorbyl glucoside/PBS repeat6 (2.768Kb)

Publication date

2019-03-15

Creators

Starr, Nichola

Scurr, David

Metadata

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Description

This research explores the use of ToF-SIMS 3D profiling to provide information on the skin permeation of active compounds, specifically vitamin C delivery from different formulation types.

External URI

https://rdmc.nottingham.ac.uk/handle/internal/6178

DOI

http://doi.org/10.17639/nott.6171

Subjects

Colloids
Gels (Pharmacy)
Vitamin C
Skin permeation, supramolecular hydrogel, permeation enhancer, vitamin C, ToF-SIMS, depth profiling.
Subjects Allied to Medicine::Anatomy, physiology & pathology
Subjects Allied to Medicine::Pharmacology, toxicology & pharmacy
Q Science::QD Chemistry::QD 71 Analytical chemistry

Divisions

University of Nottingham, UK Campus::Faculty of Science::School of Pharmacy

Deposit date

2019-03-15

Corporate creators

Walgreens Boots Alliance

Data type

ToF-SIMS ion intensities presented as text files

Contributors

Khuriah, Abdul Hamid
Pérez-García, Luïsa

Funders

Engineering & Physical Sciences Research Council
Walgreens Boots Alliance
Innovate UK (KTP Partnership)
EU ERDF (FEDER) and the Spanish Government

Grant number

EP/I01375X/1
KTP grant no. 510929
TEC2017-85059-C3-2-R

Collection dates

January 2016-January 2018

Data collection method

ToF-SIMS SurfaceLab 6 Software

Resource languages

en

Publisher

The University of Nottingham