Show simple item record

dc.contributor.authorTomczynska, Magdalena M.
dc.contributor.authorDe Focatiis, Davide
dc.contributor.authorWard, Michael
dc.contributor.authorChoong, Gabriel Y. H.
dc.contributor.authorCanciani, Alessia
dc.contributor.authorWalton, Kirsty
dc.contributor.authorGrant, David M.
dc.contributor.authorIrvine, Derek J.
dc.contributor.authorParsons, Andrew J.
dc.description.abstractThe load bearing capacity of biodegradable polymeric medical devices remains limited; an improvement in mechanical properties is desirable to widen the range of applications. Incorporation of nanoparticles is explored to increase the mechanical properties of the base matrix whilst maintaining desirable polymeric processing routes. Various nanomaterials have been investigated for polylactic acid (PLA) reinforcement for orthopaedic applications; hydroxyapatite (HA), the main inorganic constituent of bone, is one of the most promising bioresorbable nanofillers. However, uncoated nanoparticles agglomerate easily during compounding; tailored coatings can offer new opportunities to improve dispersion. This study investigates the effectiveness of novel tailored dispersants on particle dispersion, rheological properties and on macroscopic mechanical properties, when coated onto HA nanoparticles (HANP). The dispersants consist of short-chain PLA with isosorbide head groups (isPLA), or neat dodecenylsuccinic anhydride (DDSA). HANP were synthesised via a hydrothermal counter-flow process with dispersant coatings added in-situ. Neat DDSA was purchased whilst isPLA was polymerised via a standard ring-opening route involving lactide, a tin catalyst and isosorbide initiator. Nanocomposites were compounded in a twin-screw recirculating extruder and assessed by TEM, rheology and mechanical measurements.en_UK
dc.publisherThe University of Nottinghamen_UK
dc.subject.lcshBiomedical engineeringen_UK
dc.subject.lcshBiomedical materials -- Biodegradationen_UK
dc.subject.lcshPolymeric composites -- Biodegradation.en_UK
dc.subject.lcshPolymeric composites -- Mechanical propertiesen_UK
dc.subject.lcshPolylactic aciden_UK
dc.subject.lcshNanostructured materialsen_UK
dc.subject.lcshOrthopedic apparatusen_UK
dc.subject.lcshDispersing agentsen_UK
dc.subject.lcshTransmission electron microscopyen_UK
dc.subject.lcshGel permeation chromatographyen_UK
dc.titleProcessing and properties of PLA-HA nanocomposites: the effect of particle morphology and dispersantsen_UK
dc.subject.freeMelt compounding, extrusion, GPC, TGA, mechanical testingen_UK
dc.subject.jacsJACS Subjects::Engineering::General engineering::Bioengineering, biomedical engineering & clinical engineeringen_UK
dc.subject.lcLibrary of Congress Subject Areas::R Medicine::R Medicine (General)::R855 Medical technology. Biomedical engineering. Electronicsen_UK 2014 - Mar. 2016en_UK
uon.divisionFaculties, Schools and Departments::University of Nottingham, UK Campus::Faculty of Engineering::Department of Mechanical, Materials and Manufacturing Engineeringen_UK
uon.funder.controlledFunders::Engineering & Physical Sciences Research Councilen_UK
uon.datatypeExcel files for: Melt compounding, Mechanical Testing, GPC, TGAen_UK
uon.parentprojectIntegrated Molecular Design of Melt-processable Bioresorbable Engineering Nanocomposites for Health-Care (BENcH)en_UK
uon.rightscontactUniversity of Nottinghamen_UK

Files in this item


This item appears in the following Collection(s)

  • Public Research Data
    A collection of research data, held in this repository, that is publicly available, except where individual embargoes apply

Show simple item record