Identification of a discrete population of CD8+ effector memory cells linked to immune checkpoint inhibitor-induced liver injury

Abstract

Anonymised mass cytometry data collected from patients with drug-induced liver injury and autoimmune hepatitis, and associated controls. Data acquired using a Helios mass cytometer on whole blood samples stained using the Maxpar Direct Immune Profiling assay kit. Samples have been preprocessed (normalisation, gating on gaussian parameters and live/dead stain), and values have been arcsinh transformed with a cofactor of 5, no further filtering or clustering has been carried out.