Browsing by Subject "Macrophages"
Now showing items 1-5 of 5
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Data for Discovery of synergistic material-topography combinations to achieve immunomodulatory osteoinductive biomaterials using a novel in vitro screening method: The ChemoTopoChip
(The University of Nottingham, 2020-09-18)Human mesenchymal stem cells (hMSCs) are widely represented in regenerative medicine clinical strategies due to their compatibility with autologous implantation. Effective bone regeneration involves crosstalk between ... -
Functional Interleukin-4 releasing microparticles impact THP-1 differentiated macrophage phenotype
(The University of Nottingham, 2024-10-25)Macrophage cell therapies offer potential treatment in inflammatory diseases due to their ability to mobilize and stimulate their environment. However, successful treatment requires a pro-regenerative macrophage phenotype ... -
Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation
(The University of Nottingham, 2020-05-05)Material topography is known to influence macrophage attachment and phenotype, providing opportunities for the rational design of ‘immune-instructive’ topographies to modulate macrophage function and thus foreign body ... -
Immune-instructive polymers
(The University of Nottingham, 2020-05-01)We identify polymers which instruct different immunological responses by modulating macrophage attachment and polarisation to pro-inflammatory (M1-like) or anti-inflammatory (M2-like) phenotypes. These immune-instructive ... -
Single cell metabolic profiling of macrophages using 3D OrbiSIMS: correlations with phenotype
(The University of Nottingham, 2022-06-10)ABSTRACT: Macrophages are important immune cells that respond to environmental cues acquiring a range of activation status represented by pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes at each end of their ...