An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 6535R-1

Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’.

RNAi line: 6535R-1 (III)
Source: NIG

Name: tefu (1)
Full name: telomere fusion
Also known as: ATM, dATM, atm/tefu
Annotation symbol: CG6535
FlyBase ID: FBgn0045035

File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)

Included files: 031014.lei - lgl 653R1 An9.tif 091014_an10_6535r1_w_combined.tif 091014_An11_6535r1_w_combined.tif 091014_An9_6535r1_w1_combined.tif 091014_An9_6535r1_w2_combined.tif 101014_lgl_6535R1_An9_combined.tif