An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 6131

Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’.

RNAi line: 6131 (III)
Source: VDRC

Name: para (1)
Full name: paralytic
Also known as: bss, sbl, olfD, DmNav, DmNav1
Annotation symbol: CG9907
FlyBase ID: FBgn0285944

File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)

Included files: 040414_lgl_6131_Animal8_combined.tif 090414_Lgl6131An1_combined.tif 090414_Lgl6131An3_combined.tif 100414_lgl_6131_Animal5_combined.tif 100414_lgl_6131_Animal6_combined.tif