An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 10692

Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’.

RNAi line: 10692 (III)
Source: VDRC

Name: p53 (1)
Full name: p53
Also known as: Dmp53, dp53
Annotation symbol: CG33336
FlyBase ID: FBgn0039044

File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)

Included files: 120713.lei - Lgl10692An2w1.tif 120713_Lgl10692An2w1_combined.tif 190713.lei - Lgl10692An1w1.tif 190713.lei - Lgl10692An2w1.tif 190713.lei - Lgl10692An2w2.tif 190713.lei - Lgl10692An3w1.tif 190713.lei - Lgl10692An3w2.tif 190713_Lgl10692An1w1_combined.tif 190713_Lgl10692An2w1_combined.tif 190713_Lgl10692An2w2_combined.tif 190713_Lgl10692An3w1_combined.tif 190713_Lgl10692An3w2_combined.tif 190713_Lgl10692An4w1_combined.tif 190713_Lgl10692An4w2_combined.tif 191212b_Lgl3_10692_an5_w1_combined.tif 191212b_Lgl3_10692_an5_w2_combined.tif 200613_lgl_10692gd_combined.tif 201212b_Lgl3_10692_an9_w_combined.tif 230813.lei - Lgl10692An6w1.tif 230813_Lgl10692An6w1_combined.tif 260613_An9_Lgl_10692_w1_combined.tif 260613_An9_Lgl_10692_w2_combined.tif