Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’.
RNAi line: 8203R-3 (III)
Full name: Cyclin-dependent kinase 5
Also known as:
Annotation symbol: CG8203
FlyBase ID: FBgn0013762
File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
Included files: 130913_Lgl8203R3An2w1_combined.tif 130913_Lgl8203R3An2w2_combined.tif 130913_Lgl8203R3An3w1_combined.tif 130913_Lgl8203R3An3w2_combined.tif 130913_Lgl8203R3An4w1_combined.tif 130913_Lgl8203R3An4w2_combined.tif 190713_Lgl8203R3An6w1_combined.tif 230713_Lgl8203R3An3w1_combined.tif 230713_Lgl8203R3An3w2_combined.tif 230713_Lgl8203R3An7w1_combined.tif 230713_Lgl8203R3An7w2_combined.tif 230713_Lgl8203R3An8w1_combined.tif 250613_Lgl8203R3An7w1_combined.tif 250613_Lgl8203R3An7w2_combined.tif 260613_An5_Lgl_8203R3_w_combined.tif 260613_An6_Lgl_8203R3_w1_combined.tif 260613_An6_Lgl_8203R3_w2_combined.tif